A genetic disease may be caused by mutations in
a single cell. There are six different models by which genetic
disorders can be inherited, depending on which gene is involved. Genetic
diseases can be inherited by autosomal dominant, autosomal recessive,
X-linked dominant, X-linked recessive, codominant and mitochondrial.
In autosomal dominant, which is an altered copy of the genes is
sufficient for an individual to be affected by an autosomal dominant.
The person affected by it has a parent who is also affected. The
scientists concluded that autosomal dominant diseases occur in each
generation of a family affected. Membership in this group are diseases
such as neurofibromatosis type 1 and Huntington's disease.
When two copies of a mutated gene and is present in every cell of an
individual, therefore, autosomal recessive is the standard by which
genetic disorders follow. In this pattern, the person affected by it
have parents who are not affected, but each carries a single copy of the
mutated gene. Here, parents are called carriers of the gene and
autosomal recessive disorders not occurring in every generation of a
family affected. Diseases that have an autosomal recessive pattern are
cystic fibrosis and sickle cell anemia.
For a genetic disease to be labeled X-linked dominant genetic mutations
that occur in the X chromosome, and thus make women more vulnerable to
developing diseases such as fragile X syndrome. Furthermore, the
possibility of transmitting the disease X-linked dominant differs
between women and men. However, in each generation of the family
concerned, both men and women are often affected. A curious feature of
disease X-linked dominant is that men can not transmit the disease to
their children.
In X-linked recessive disease, mutations in the gene also occur on the X
chromosome However, the difference is that here, men are more
vulnerable than females. And while the likelihood of transmission of the
disease varies between men and women in affected families, men tend to
be affected in each generation. In addition, children can not inherit
from his parents linked recessive diseases such as hemophilia and X
Fabry disease.
Codominant disease has two different versions of genes that are
expressed, with each version having a tiny variation in protein.
However, the genes influencing the genetic characteristics of the
disease. An example of a disease considered to have co-dominant pattern
is the alpha-1 antitrypsin.
Another term for the employer to obtain mitochondrial genetic disorders
is maternal inheritance, which refers to the mutated genes in
mitochondrial DNA. Mitochondria convert energy molecules, with each
molecule containing a small amount of DNA. Only women can transmit
mitochondrial mutations to their children, because only eggs contribute
mitochondria to the developing embryo. Diseases due to mitochondrial
mutations can occur in all generations of the family concerned. Also
affect men and women, however, children inherit mitochondrial genetic
disorders from their mothers alone.
In addition to the above models, other diseases are caused by the
interaction between environment and the genes or by combining the
effects of various genes. These diseases are difficult to analyze due to
genetic causes bleak. Examples of such diseases as diabetes,
schizophrenia, heart disease and some cancers.
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